Description of the dosage form

Dry amorphous porous mass, compacted in the form of a tablet, or white or almost white powder.

Pharmacokinetics 

After intramuscular injection, it is well absorbed.  The half-life is 8 hours. The maximum concentration of HCG in the blood plasma is reached after 4-12 hours.  The half-life of chorionic gonadotropin is 29-30 hours, in the case of daily intramuscular injections, cumulation of the drug may occur.  Chorionic gonadotropin is excreted by the kidneys.  About 10-20% of the administered dose is found unchanged in the urine, the main part is excreted as fragments of the β-chain.

Pharmacodynamics 

It has a gonadotropic effect, follicle-stimulating and luteinizing.

Luteinizing activity prevails over follicle-stimulating.  Stimulates the development of the genital organs and secondary sexual characteristics.  In women, the drug causes ovulation and stimulates the synthesis of estrogens (estradiol) and progesterone.  In men, it stimulates spermatogenesis, the production of testosterone and dihydrotestosterone.

Pharmacological properties 

Human chorionic gonadotropin (HCG) is a gonadotropic hormone that is produced by the placenta during pregnancy and then excreted unchanged by the kidneys.  To obtain the drug, it is extracted from the urine and purified.  Necessary for normal growth and maturation of gametes in women and men, as well as for the production of sex hormones.